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ESTABLISHMENT AND CRYPTIC TRANSMISSION OF ZIKA VIRUS IN BRAZIL AND THE AMERICAS
https://www.arca.fiocruz.br/handle/icict/19085
AUTHORS: R.N. Faria*,1,2, J. Quick3,*, I. Morales4,*, J. Thézé1,*, J.G. Jesus5,*, M. Giovanetti5,6,*, M. U. G. Kraemer1,7,8,*, S. C. Hill1,*, A. Black9,10,*, A. C. da Costa4, L. C. Franco2, S. P. Silva2, C.-H. Wu11, J. Raghwani1, S. Cauchemez12,13, L. du Plessis1, M. P. Verotti14, W. K. de Oliveira15,16, E. H. Carmo17, G. E. Coelho18,19, A. C. F. S. Santelli18,20, L. C. Vinhal18, C. M. Henriques17, J. T. Simpson21, M. Loose22, K. G. Andersen23, N. D. Grubaugh23, S. Somasekar24, C. Y. Chiu24, J. E. Muñoz-Medina25, C. R. Gonzalez-Bonilla25, C. F. Arias26, L. L. Lewis-Ximenez27, S.A. Baylis28, A. O. Chieppe29, S. F. Aguiar29, C. A. Fernandes29, P. S. Lemos2, B. L. S. Nascimento2, H. A. O. Monteiro2, I. C. Siqueira5, M. G. de Queiroz30, T. R. de Souza30,31, J. F. Bezerra30,32, M. R. Lemos33, G. F. Pereira33, D. Loudal33, L. C. Moura33, R. Dhalia34, R. F. França34, T. Magalhães34, E. T. Marques Jr.34,35, T. Jaenisch36, G. L. Wallau34, M. C. de Lima37, V. Nascimento37, E. M. de Cerqueira38, M. M. de Lima38, D. L. Mascarenhas39, J. P. Moura Neto40, A. S. Levin4, T. R. Tozetto-Mendoza4, S. N. Fonseca41, M. C. Mendes-Correa4, F.P. Milagres42, A. Segurado4, E. C. Holmes43, A. Rambaut44,45, T. Bedford9, M. R. T. Nunes*,2,46, E. C. Sabino4, L. C. J. Alcantara5, N. Loman3, and O. G. Pybus1,47, - AFFILIATIONS - Affiliations1Department of Zoology, University of Oxford, Oxford OX3 1PS, UK2Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil3Institute of Microbiology and Infection, University of Birmingham, UK4Department of Infectious Disease, School of Medicine & Institute of Tropical Medicine, University of São Paulo, Brazil5Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil6University of Rome Tor Vergata, Rome, Italy7Harvard Medical School, Boston, MA, USA8Boston Children’s Hospital, Boston, MA, USA9Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA10Department of Epidemiology, University of Washington, Seattle, WA, USA11Department of Statistics, University of Oxford, Oxford OX3 1PS, UK12Mathematical Modelling of Infectious Diseases and Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris, France13Centre National de la Recherche Scientifique, URA3012, Paris, France 14Coordenação dos Laboratórios de Saúde (CGLAB/DEVIT/SVS), Ministry of Health, Brasília, Brazil. Brazil15Coordenação Geral de Vigilância e Resposta às Emergências em Saúde Pública (CGVR/DEVIT), Ministry of Health, Brasília, Brazil16Center of Data and Knowledge Integration for Health (CIDACS), Fundação Oswaldo Cruz (FIOCRUZ), Brazil17Departamento de Vigilância das Doenças Transmissíveis, Ministry of Health, Brasilia, Brazil18Coordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes, Ministry of Health, Brasília, Brazil19Pan American Health Organization (PAHO), Buenos Aires, Argentina20Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil21Ontario Institute for Cancer Research, Toronto, Canada. R. N. Faria. University of Oxford. Department of Zoology. Oxford, England / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. J. Quick. University of Birmingham. Institute of Microbiology and Infection. Birmingham, West Midlands, United Kingdom.
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Resumen en ingles
Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil1. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 20162) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 20162). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease3. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly. Here we address this issue by generating 54 complete or partial ZIKV genomes, mostly from Brazil, and reporting data generated by a mobile genomics laboratory that travelled across northeast Brazil in 2016. One sequence represents the earliest confirmed ZIKV infection in Brazil. Analyses of viral genomes with ecological and epidemiological data yield an estimate that ZIKV was present in northeast Brazil by February 2014 and is likely to have disseminated from there, nationally and internationally, before the first detection of ZIKV in the Americas. Estimated dates for the international spread of ZIKV from Brazil indicate the duration of pre-detection cryptic transmission in recipient regions. The role of northeast Brazil in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the basic reproduction number of the virus.
Editor
Nature Publishing Group
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Referencia
LEWIS-XIMENES, Lia L. et al. Establishment and cryptic transmission of Zika virus in Brazil and the Americas. Nature, v. 546, n. 7658, p. 406-410, June 2017.DOI
10.1038/nature22401ISSN
0028-0836Notas
Melgaço, Juliana Gil; Lewis-Ximenez, Lia L. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. C. M. Henriques; J. G. de Jesus; W. K. de Oliveira. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil. G. L. Wallau. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. C. M. Henriques. Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.AUTHORS: R.N. Faria*,1,2, J. Quick3,*, I. Morales4,*, J. Thézé1,*, J.G. Jesus5,*, M. Giovanetti5,6,*, M. U. G. Kraemer1,7,8,*, S. C. Hill1,*, A. Black9,10,*, A. C. da Costa4, L. C. Franco2, S. P. Silva2, C.-H. Wu11, J. Raghwani1, S. Cauchemez12,13, L. du Plessis1, M. P. Verotti14, W. K. de Oliveira15,16, E. H. Carmo17, G. E. Coelho18,19, A. C. F. S. Santelli18,20, L. C. Vinhal18, C. M. Henriques17, J. T. Simpson21, M. Loose22, K. G. Andersen23, N. D. Grubaugh23, S. Somasekar24, C. Y. Chiu24, J. E. Muñoz-Medina25, C. R. Gonzalez-Bonilla25, C. F. Arias26, L. L. Lewis-Ximenez27, S.A. Baylis28, A. O. Chieppe29, S. F. Aguiar29, C. A. Fernandes29, P. S. Lemos2, B. L. S. Nascimento2, H. A. O. Monteiro2, I. C. Siqueira5, M. G. de Queiroz30, T. R. de Souza30,31, J. F. Bezerra30,32, M. R. Lemos33, G. F. Pereira33, D. Loudal33, L. C. Moura33, R. Dhalia34, R. F. França34, T. Magalhães34, E. T. Marques Jr.34,35, T. Jaenisch36, G. L. Wallau34, M. C. de Lima37, V. Nascimento37, E. M. de Cerqueira38, M. M. de Lima38, D. L. Mascarenhas39, J. P. Moura Neto40, A. S. Levin4, T. R. Tozetto-Mendoza4, S. N. Fonseca41, M. C. Mendes-Correa4, F.P. Milagres42, A. Segurado4, E. C. Holmes43, A. Rambaut44,45, T. Bedford9, M. R. T. Nunes*,2,46, E. C. Sabino4, L. C. J. Alcantara5, N. Loman3, and O. G. Pybus1,47, - AFFILIATIONS - Affiliations1Department of Zoology, University of Oxford, Oxford OX3 1PS, UK2Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil3Institute of Microbiology and Infection, University of Birmingham, UK4Department of Infectious Disease, School of Medicine & Institute of Tropical Medicine, University of São Paulo, Brazil5Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil6University of Rome Tor Vergata, Rome, Italy7Harvard Medical School, Boston, MA, USA8Boston Children’s Hospital, Boston, MA, USA9Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA10Department of Epidemiology, University of Washington, Seattle, WA, USA11Department of Statistics, University of Oxford, Oxford OX3 1PS, UK12Mathematical Modelling of Infectious Diseases and Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris, France13Centre National de la Recherche Scientifique, URA3012, Paris, France 14Coordenação dos Laboratórios de Saúde (CGLAB/DEVIT/SVS), Ministry of Health, Brasília, Brazil. Brazil15Coordenação Geral de Vigilância e Resposta às Emergências em Saúde Pública (CGVR/DEVIT), Ministry of Health, Brasília, Brazil16Center of Data and Knowledge Integration for Health (CIDACS), Fundação Oswaldo Cruz (FIOCRUZ), Brazil17Departamento de Vigilância das Doenças Transmissíveis, Ministry of Health, Brasilia, Brazil18Coordenação Geral dos Programas de Controle e Prevenção da Malária e das Doenças Transmitidas pelo Aedes, Ministry of Health, Brasília, Brazil19Pan American Health Organization (PAHO), Buenos Aires, Argentina20Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil21Ontario Institute for Cancer Research, Toronto, Canada. R. N. Faria. University of Oxford. Department of Zoology. Oxford, England / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. J. Quick. University of Birmingham. Institute of Microbiology and Infection. Birmingham, West Midlands, United Kingdom.
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