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ArtigoDireito Autoral
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- IOC - Artigos de Periódicos [12642]
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CYSTEINE PROTEASES AS DIGESTIVE ENZYMES IN PARASITIC HELMINTHS
Afiliação
University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. Center for Discovery and Innovation in Parasitic DiseasesLa Jolla. Center for Discovery and Innovation in Parasitic Diseases. CA, USA.
University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. Center for Discovery and Innovation in Parasitic DiseasesLa Jolla. Center for Discovery and Innovation in Parasitic Diseases. CA, USA / University of San Francisco. Department of Biology. San Francisco, CA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Rio de Janeiro, RJ, Brasil.
Queen´s University Belfast. Medical Biology Centre. School of Biological Sciences. Belfast, United Kingdom.
Queen´s University Belfast. Medical Biology Centre. School of Biological Sciences. Belfast, United Kingdom.
University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. Center for Discovery and Innovation in Parasitic DiseasesLa Jolla. Center for Discovery and Innovation in Parasitic Diseases. CA, USA / University of San Francisco. Department of Biology. San Francisco, CA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Rio de Janeiro, RJ, Brasil.
Queen´s University Belfast. Medical Biology Centre. School of Biological Sciences. Belfast, United Kingdom.
Queen´s University Belfast. Medical Biology Centre. School of Biological Sciences. Belfast, United Kingdom.
Resumo em Inglês
We briefly review cysteine proteases (orthologs of mammalian cathepsins B, L, F, and C) that are expressed in flatworm and nematode parasites. Emphasis is placed on enzyme activities that have been functionally characterized, are associated with the parasite gut, and putatively contribute to degrading host proteins to absorbable nutrients [1-4]. Often, gut proteases are expressed as multigene families, as is the case with Fasciola [5] and Haemonchus [6], presumably expanding the range of substrates that can be degraded, not least during parasite migration through host tissues [5]. The application of the free-living planarian and Caenorhabditis elegans as investigative models for parasite cysteine proteases is discussed. Finally, because of their central nutritive contribution, targeting the component gut proteases with small-molecule chemical inhibitors and understanding their utility as vaccine candidates are active areas of research [7].
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