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GLOBAL INFLUENZA HOSPITAL-BASED SURVEILLANCE NETWORK (GIHSN): RESULTS OF SURVEILLANCE OF INFLUENZA AND OTHER RESPIRATORY VIRUSES IN HOSPITALISED PATIENTS IN BRAZIL, 2015
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Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil / Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Paraná. Programa de Pós-graduação em Medicina Interna e Ciências da Saúde. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.
Hospital Quinta D'Or. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Rio de Janeiro, RJ, Brasil.
Fondation Merieux. Scientific Department. Lyon, France.
Fondation Merieux. Scientific Department. Lyon, France.
FISABIO-Public Health. Vaccines Research. Valencia, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.
Global Influenza Hospital-based Surveillance Network
Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Paraná. Programa de Pós-graduação em Medicina Interna e Ciências da Saúde. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.
Hospital Quinta D'Or. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Rio de Janeiro, RJ, Brasil.
Fondation Merieux. Scientific Department. Lyon, France.
Fondation Merieux. Scientific Department. Lyon, France.
FISABIO-Public Health. Vaccines Research. Valencia, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.
Global Influenza Hospital-based Surveillance Network
Abstract
Background Influenza-like illness occurs annually
worldwide, with peak timing and severity varying
seasonally, resulting in significant annual mortality.
Objectives There were three objectives: (1) to describe
the epidemiological and clinical features of hospitalised
patients with severe acute respiratory infection caused by
influenza and other respiratory viruses (ORVs); (2) to report
the influenza seasonality in the region and (3) to correlate
findings of influenza circulation and immunisation time in
Brazil.
Patients/methods This study took place in three Brazilian
hospitals located in cities with different climatic conditions
(Curitiba (south), Rio de Janeiro (south-east) and Fortaleza
(north-east)). Patients presenting with an acute process
with indication for admission consisting of a predefined set
of conditions potentially associated with recent influenza
infection were enrolled.
Results We screened 1666 patients, with 595 meeting
the inclusion criteria. Influenza viruses and ORVs were
detected in 6.5% and 59% of patients, respectively.
Influenza-positive cases fell into the severe spectrum as
compared with those with ORVs (30% vs 11%), but without
any difference in mortality rates. Epidemiological results
revealed variations in the peak time of influenza infections
between north-east (Fortaleza) and south (Curitiba) Brazil,
basically following the rain period of each region. In
north-east Brazil, viral circulation was prevalent in the
first 4 months of the year, indicating that the vaccination
campaign occurred in a postseasonal period, possibly
explaining the low effectiveness.
Conclusions The active-surveillance model is a
valuable tool for investigating respiratory virus impact on
hospitalised patients, with influenza-infection monitoring
enabling implementation of adequate preventive
measures.
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