Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/2820
IMAGING EXAMS OF BONE LESIONS IN PATIENTS WITH DIFFUSE CUTANEOUS LEISHMANIASIS (DCL)
Adulto
Osso e Ossos
Feminino
Humanos
Leishmaniose Tegumentar Difusa
Masculino
Bone alterations
Scintigraphy
Imaging exams
Autor(es)
Afiliação
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil.
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
University of São Paulo. Laboratory of Immunopathology (LIM-50). São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
University of São Paulo. Laboratory of Immunopathology (LIM-50). São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Resumo em Inglês
We studied bone lesion alterations in three patients with diffuse cutaneous leishmaniasis (DCL) by imaging exams (radiography
and scintigraphy) and histopathology. Two patients had bone lesions of distal extremities of hands and feet, and one
infiltrating plaques in the skin. The study was conducted at three specialized centers (Presidente Dutra Hospital/Nucleus of Tropical
Pathology, UFMA-MA; Gonc¸alo Moniz Research Center-FIOCRUZ-BA; Laboratory of Pathology of Infectious Diseases
(LIM-50), University of S˜ao Paulo, SP). Three-phase bone scintigraphy demonstrated high sensitivity and specificity for bone
lesions, showing increased uptake of the radiopharmaceutical at sites of active lesions. In contrast, radiography demonstrated
lytic lesions, cortical destruction and local osteopenia of the bone extremeties in two patients. Histopathological analysis showed
sequestration with presence of amastigote forms of Leishmania (osteomyelitis), mononuclear cells and macrophages containing
amastigote forms of Leishmania in one patient. These preliminary data indicate that imaging exams (radiography and scintigraphy)
are important in the evaluation of bone lesions in diffuse cutaneous leishmaniasis and should be included in the routine
histopathological diagnosis of the disease and follow-up of bone lesions
Palavras-chave
AdolescenteAdulto
Osso e Ossos
Feminino
Humanos
Leishmaniose Tegumentar Difusa
Masculino
Palavras-chave em inglês
Diffuse cutaneous LeishmaniasisBone alterations
Scintigraphy
Imaging exams
Compartilhar