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ON THE PRESENCE OF HEPATIC STELLATE CELLS IN PORTAL SPACES
Hepatócitos
Cirrose Hepática
Sistema Porta
Histocitoquímica
Animais
Camundongos
Ratos Wistar
Autor
Afiliación
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Resumen en ingles
Previous studies in mice with hypervitaminosis A have demonstrated that fat-storing cells (hepatic stellate cells-
HSCs) participate in schistosomal granuloma fibrogenesis. The origin of such cells in portal areas, away from the
Disse spaces, was herein investigated. HSCs were identified in frozen sections of the liver by means of Sudan III
staining. They appeared as red-stained cells disposed along the sinusoids of normal mice, but were never found
within portal spaces. However, in the chronically inflamed portal spaces of Capillaria hepatica-infected mice, Sudan
III-positive cells were frequently present among leukocytes and fibroblast-like cells. Thus, there are no resident
HSCs in portal spaces, but their presence there in chronic inflammatory processes indicates that they are able to
migrate from peri-sinusoidal areas in order to reach the portal areas
Palabras clave en portugues
Espaço ExtracelularHepatócitos
Cirrose Hepática
Sistema Porta
Histocitoquímica
Animais
Camundongos
Ratos Wistar
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