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https://www.arca.fiocruz.br/handle/icict/28181
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ArtículoDerechos de autor
Acceso restringido
Fecha del embargo
2030-01-01
Objetivos de Desarrollo Sostenible
05 Igualdade de gêneroColecciones
- IOC - Artigos de Periódicos [12747]
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THE IMPACT OF INFECTIOUS DISEASES UPON NEUROENDOCRINE CIRCUITS
Glucocorticoides
Hormônios Esteroides Gonadais
Citocinas
Extracellular matrix
Eixo hipotálamo-hipófise-adrenal
Infecções por patógenos intracelulares
Atrofia do timo
Intracellular pathogen infections
thymus
Glucocorticoids
Sex hormones
Cytokines
Extracellular matrix
Thymic atrophy
Afiliación
National University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina.
National University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
National University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
Resumen en ingles
During infectious diseases, neuroendocrine and immune networks act in concert, facilitating host response. It is known that infections cause profound immune changes, but the impact upon immunoendocrine circuits has been less studied. Disorders in the hypothalamic-pituitary-adrenal (HPA) axis were frequently observed associated with infections, and these changes often occur in parallel to alterations in the systemic cytokine network. Explanations for the infection-associated immunoendocrine disturbances include several and not mutually exclusive possibilities. Changes in cytokine levels can enhance or suppress the HPA axis, by acting at the hypothalamus-pituitary unit and/or at the adrenal glands. In situ inflammatory reactions or structural changes like vascular alterations or an enhanced extracellular matrix deposition in the endocrine microenvironment may also lead to a transient HPA dysfunction. Lastly, a microbe-related effect by means of pathogen infiltration or exploitation of the host's hormonal microenvironment may be involved as well. A better understanding of the relevance of immunoendocrine communication during infectious diseases, and how disturbances in the flux of information lead to neuroendocrine immune-related disorders will provide important insights into mechanisms underlying the disease pathology.
Palabras clave en portugues
TimoGlucocorticoides
Hormônios Esteroides Gonadais
Citocinas
Extracellular matrix
Eixo hipotálamo-hipófise-adrenal
Infecções por patógenos intracelulares
Atrofia do timo
Palabras clave en ingles
Hypothalamus-pituitary-adrenal axisIntracellular pathogen infections
thymus
Glucocorticoids
Sex hormones
Cytokines
Extracellular matrix
Thymic atrophy
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