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HEMOCYTE DIFFERENTIATION MEDIATES INNATE IMMUNE MEMORY IN ANOPHELES GAMBIAE MOSQUITOES
Rodrigues, Janneth et al. | Fecha del documento: 2010
Autor
Rodrigues, Janneth
Brayner, Fábio André
Alves, Luiz Carlos
Dixit, Rajnikant
Barillas-Mury, Carolina
Afiliación
tional Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães and LIKA-UFPE. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães and LIKA-UFPE. Recife, PE, Brasil.
National Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA.
National Institute of Allergy and Infectious Diseases. National Institutes of Health Laboratory of Malaria and Vector Research. Rockville, MD, USA.
Resumen en ingles
Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory.
Palabras clave en portugues
Mosquito
Sistema Imune
Imunidade Inata
 
DeCS
Anopheles / imunologia
Anopheles / parasitologia
Bactérias / imunologia
Hemócitos / fisiologia
Imunidade Inata
Memória Imunológica
Plasmodium berghei / imunologia
Ratos
Diferenciação Celular
Contagem de Colônias, Microbiana
 
Referencia
RODRIGUES, J. et al. Hemocyte Differentiation Mediates Innate Immune Memory in Anopheles gambiae Mosquitoes. Science, v. 329, n. 5997, p. 1353–1355, 10 set. 2010.
DOI
10.1126/science.1190689
ISSN
1095-9203