Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/27689
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2030-01-01
Coleções
- BA - IGM - Artigos de Periódicos [3674]
- IOC - Artigos de Periódicos [12642]
Metadata
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CARRIAGE OF LEPTOSPIRA INTERROGANS AMONG DOMESTIC RATS FROM AN URBAN SETTING HIGHLY ENDEMIC FOR LEPTOSPIROSIS IN BRAZIL
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil / Embrapa Amazônia Oriental. Belém, PA, Brasil.
Brigham and Women’s Hospital. Department of Medicine. Boston, USA.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil.
Royal Tropical Institute. Department of Biomedical Research. Amsterdam, The Netherlands.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil / Weill Medical College of Cornell University. Division of International Medicine and Infectious Disease. New York, NY, USA.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.
Brigham and Women’s Hospital. Department of Medicine. Boston, USA.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil.
Royal Tropical Institute. Department of Biomedical Research. Amsterdam, The Netherlands.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil / Weill Medical College of Cornell University. Division of International Medicine and Infectious Disease. New York, NY, USA.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.
Resumo em Inglês
A survey was conducted to identify reservoirs for urban leptospirosis in the city of Salvador, Brazil. Sampling protocols were performed in the vicinity of households of severe leptospirosis cases identified during active hospital-based surveillance. Among a total of 142 captured Rattus norvegicus (Norwegian brown rat), 80.3% had a positive culture isolate from urine or kidney specimens and 68.1% had a positive serum sample by microscopic agglutination test (MAT) titre of > or = 1:100. Monoclonal antibody-based typing of isolates identified that the agent carried by rats was Leptospira interrogans serovar Copenhageni, which was the same serovar isolated from patients during hospital-based surveillance. Leptospira spp. were not isolated from 8 captured Didelphis marsupialis (Opossum), while 5/7 had a positive MAT titre against a saprophytic serogroup. R. rattus were not captured during the survey. The study findings indicate that the brown rat is a major rodent reservoir for leptospirosis in this urban setting. Furthermore, the high carriage rates of L. interrogans serovar Copenhageni in captured rats suggest that there is a significant degree of environmental contamination with this agent in the household environment of high risk areas, which in turn is a cause of transmission during urban epidemics.
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