Currently, cutaneous adverse drug reactions are a growing problem in which diagnosis can be challenging due to the existence of multiple drugs, diverse pharmacological interactions and symptoms that mimic a large variety of skin diseases. We report a case of a 23-year-old female patient that presented a 3-year history of dysuria, vulvar bleeding and painful oral ulcerations that healed spontaneously in approximately 10 days (Figure 1). The episodes were sporadic, but the symptoms became more exuberant with every relapse, leading to conjunctival hyperemia and eyelid edema. Systemic lupus erythematosus and Behçet’s disease were considered. Laboratory tests, including viral serologies, ANF, ESR and ANCA showed normal results and pathergy test was negative.