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https://www.arca.fiocruz.br/handle/icict/27291
Tipo de documento
ArtigoDireito Autoral
Acesso aberto
Objetivos de Desenvolvimento Sustentável
03 Saúde e Bem-EstarColeções
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MOLECULAR EVIDENCE OF HORIZONTAL TRANSMISSION OF HEPATITIS C VIRUS WITHIN COUPLES
Hepacivirus
Disease Transmission, Infectious
RNA, Viral
Phylogeny
Autor(es)
Afiliação
Instituto Butantan. Laboratório de Imunologia Viral. São Paulo, SP, Brasil / University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
Universidade de São Paulo. Instituto de Biociências. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
Universidade de São Paulo. Instituto de Biociências. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
University of São Paulo School of Medicine. Department of Gastroenterology. São Paulo, SP, Brasil
Resumo em Inglês
Hepatitis C virus (HCV) transmission has decreased with the adoption of universal blood donor screening and social policies to reduce the risk of infection in intravenous drug users, but remains a worldwide health problem. The objective of this study was to evaluate the phylogenetic relationships among sequences from different HCV genomic regions from sexual partners of infected patients. Nine couples with a stable relationship and without other risk factors for HCV infection and 42 control patients were selected, and the NS3 and NS5B regions were analysed. Phylogenetic analysis showed that viruses from five of the couples had a common origin, clustering in the same monophyletic group, with bootstrap values greater than 70. For the other couples, monophyletic groups were observed, but without bootstrap support. Thus, using two different viral genome regions, a common source of infection was observed in both members of five couples. These data strongly support HCV transmission within couples.
Palavras-chave em inglês
Hepatitis CHepacivirus
Disease Transmission, Infectious
RNA, Viral
Phylogeny
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