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https://www.arca.fiocruz.br/handle/icict/27188
MANNAN-BINDING LECTIN ENHANCES SUSCEPTIBILITY TO VISCERAL LEISHMANIASIS
Author
Affilliation
School of Public Health. Department of Immunology and Infectious Diseases. USA / Empresa Brasileira de Pesquisa Agropecuária. Centro Nacional de Pesquisa de Recursos Genéticos e Biotecnologia. Brasília, DF, Brasil
School of Public Health. Department of Immunology and Infectious Diseases. USA / Universidade Federal do Piauí. Centro de Ciências da Saúde. Departamento de Medicina Comunitária. Teresina, PI, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departmento de Parasitologia. São Paulo, SP, Brasil
Instituto Oswaldo Cruz. Departamento de Genética. Rio de Janeiro, RJ, Brasil
School of Public Health. Department of Biostatistics. USA
Massachusetts General Hospital. Laboratory of Developmental Immunology. Boston, Massachusetts
Universidade Federal do Piauí. Centro de Ciências da Saúde. Departamento de Medicina Comunitária. Teresina, PI, Brasil
School of Medicine. Division of Emergency Medicine. USA
School of Public Health. Department of Immunology and Infectious Diseases. USA
Massachusetts General Hospital. Laboratory of Developmental Immunology. Boston, Massachusetts
School of Medicine. Division of Emergency Medicine. Division of Infectious Diseases. USA
School of Public Health. Department of Immunology and Infectious Diseases. USA / Universidade Federal do Piauí. Centro de Ciências da Saúde. Departamento de Medicina Comunitária. Teresina, PI, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departmento de Parasitologia. São Paulo, SP, Brasil
Instituto Oswaldo Cruz. Departamento de Genética. Rio de Janeiro, RJ, Brasil
School of Public Health. Department of Biostatistics. USA
Massachusetts General Hospital. Laboratory of Developmental Immunology. Boston, Massachusetts
Universidade Federal do Piauí. Centro de Ciências da Saúde. Departamento de Medicina Comunitária. Teresina, PI, Brasil
School of Medicine. Division of Emergency Medicine. USA
School of Public Health. Department of Immunology and Infectious Diseases. USA
Massachusetts General Hospital. Laboratory of Developmental Immunology. Boston, Massachusetts
School of Medicine. Division of Emergency Medicine. Division of Infectious Diseases. USA
Abstract
Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.
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