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https://www.arca.fiocruz.br/handle/icict/27079
INFECTIVITY OF LEISHMANIA PROMASTIGOTES IS ASSOCIATED WITH SURFACE ANTIGENIC EXPRESSION
Interações macrofágicas
Infectividade
Expressão antigênica de superfície
Anticorpos policlonais
Macrophage interactions
Infectivity
Surface antigenic expression
Polyclonal antibodies
Autor(es)
Afiliação
Institut Pasteur. Centre d'Immunologie et de Biologie Parasitaire. Lille Cedex, France
Institut Pasteur. Centre d'Immunologie et de Biologie Parasitaire. Lille Cedex, France
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Institut Pasteur. Centre d'Immunologie et de Biologie Parasitaire. Lille Cedex, France
Institut Pasteur. Centre d'Immunologie et de Biologie Parasitaire. Lille Cedex, France
Institut Pasteur. Centre d'Immunologie et de Biologie Parasitaire. Lille Cedex, France
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Institut Pasteur. Centre d'Immunologie et de Biologie Parasitaire. Lille Cedex, France
Institut Pasteur. Centre d'Immunologie et de Biologie Parasitaire. Lille Cedex, France
Resumo em Inglês
Differentiation between a non-infective and an
infective Leishrnania promastigote population
was demonstrated. Promastigotes in the stationary
phase (day 5) were found to be highly infective
in vitro to BALB/c mouse peritoneal macrophages,
compared with those of the logarithmic
phase (day 3). The infective promastigotes
showed surface antigenic determinants different
from non-infective ones. Polyclonal anti-3 day
and anti-5 day antibodies were bound specifically
to the surface of corresponding promastigotes in
both SRIA and IFAT; no strong cross-reactions
were observed otherwise. Also, polyclonal
anti-5 day but not anti-3 day antibodies recognized
efficiently the antigenic molecules on the
surface of late stage (day 7) sandfly
promastigotes. This clearly indicates the appearance
of new antigenic molecules on the surface
of infective promastigote forms. Intracellular multiplication of Leishmania was significantly inhibited
by anti-5 day antibodies compared with
anti-3 day antibodies. The presence of new surface
molecules on late stage promastigotes may
contribute to Leishmania infectivity.
Palavras-chave
LeishmaniaInterações macrofágicas
Infectividade
Expressão antigênica de superfície
Anticorpos policlonais
Palavras-chave em inglês
LeishmaniaMacrophage interactions
Infectivity
Surface antigenic expression
Polyclonal antibodies
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