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FUNCTIONAL INTERACTIONS BETWEEN POLYPYRIMIDINE TRACT BINDING PROTEIN AND PRI PEPTIDE LIGAND CONTAINING PROTEINS.
Coelho, Miguel B. et al. | Data do documento: 2016
Autor(es)
Coelho, Miguel B.
Ascher, David Benjamin
Gooding, Clare
Lang, Emma
Maude, Hannah
Turner, David
Llorian, Miriam
Pires, Douglas Eduardo Valente
Attig, Jan
Smith, Christopher W.J.
Afiliação
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K./Fundacao Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Department of Molecular Neuroscience. UCL Institute of Neurology. Queen Square, London WC1N 3BG, U.K.
Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K.
Resumo em Inglês
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands.
Palavras-chave
emenda alternativa
ribonucleoproteína nuclear heterogênea (hnRNP)
Matrin3
proteína de ligação do trato de polipirimidina
 
Palavras-chave em inglês
alternative splicing
heterogeneous nuclear ribonucleoprotein (hnRNP)
Matrin3
polypyrimidine tract binding protein
PTB
RNA
 
Editor
Portland Press
Referência
COELHO, Miguel B et al. Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins. Biochem. Soc. Trans., v. 44, p. 1058-1065, 2016
DOI
10.1042/BST20160080
ISSN
0300-5127