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MORPHOLOGICAL AND IMMUNO-HISTOCHEMICAL CHARACTERIZATION OF FIVE PHYLLODES MAMMARY GLAND TUMORS IN DOGS
Autor
Afiliación
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Sao Paulo State University. School of Agricultural and Veterinary Sciences. Postgraduate Program of Veterinary Medicine. Jaboticabal, SP, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Sao Paulo State University. School of Agricultural and Veterinary Sciences. Postgraduate Program of Veterinary Medicine. Jaboticabal, SP, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Resumen en ingles
In
bitches, mammary tumors represent 52% of all neoplasms. The phyllodes tumor is a
rare fibro-epithelial neoplasm found in humans characterized by epithelial and
mesenchymal (stromal) cell proliferation creating elaborate leaf-like structures.
Morphological and immune-histochemical characteristics in 5 canine phyllodes tumors
are described. Four benign and one malignant phyllodes tumors were diagnosed.
Epithelial and stromal tumor cells were positive for cytokeratin AE1AE3 and vimentin,
respectively, and all were positive for estrogen and progesterone receptors. Benign
tumors were negative for p63 whereas the malignant tumor was positive for p63. Cell
proliferation index was <1% in benign tumors tissue but 69.5% in the malignant one.
All tumors were negative for c-KIT. The morphological and immune-phenotypical
aspects observed in this study suggest similarities between phyllodes tumors
diagnosed in women and in bitches. However, new studies are necessary to enhance
knowledge regarding the biological behavior of these neoplasms.
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