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EVALUATION OF MAST CELL DENSITY IN THE TUMOR MICROENVIRONMENT IN ORAL EPITHELIAL DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA
Dantas, Rebeca Carolina Moraes et al. | Data do documento: 2017
Autor(es)
Dantas, Rebeca Carolina Moraes
Souza, Renata Oliveira de
Valverde, Ludmila de Faro
Vidal, Manuela Torres Andion
Sales, Caroline Brandi Schlaepfer
Sousa, Letícia Palmeira
Santos, Jean Nunes dos
Ramos, Eduardo Antônio Gonçalves
Rocha, Clarissa Araújo Gurgel
Afiliação
University of Bahia. School of Dentistry. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
University of Bahia. Institute of Health Science. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
University of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil
Resumo em Inglês
The objective of this study was to compare mast cell density (MCD) in oral epithelial dysplasias (OED) and oral squamous cell carcinoma (OSCC) and determine its correlation with clinical and histopathologic parameters and the degree of tumor differentiation. Thirty OSCC samples, 14 OED samples, and 4 non-neoplastic oral mucosa samples were analyzed by immunohistochemistry to determineMCD based on the expression of MC tryptase. In addition, MCs were categorized morphologically into degranulated and granulated cells. MCD was significantly higher in OSCC lesions with a greater degree of differentiation (P=0.04). No significant difference inMCD was detected between mild and moderate OED samples (P=0.09). Our findings indicate that MCs are present in the tumor microenvironment and may be associated with a better prognosis
Palavras-chave
Mastocitoma
Carcinoma oral de células escamosas
Displasia epitelial oral
Densidade de mastócitos
Triptase de mastócitos
 
Palavras-chave em inglês
Mast cell
Oral squamous cell carcinoma
Oral epithelial dysplasia,
Mast cell density
Mast cell tryptase
 
Editor
Lippincott, Williams & Wilkins
Referência
DANTAS, R. C. M. et al. Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 25, n. 10, p. e83-e88, 2017.
ISSN
1541-2016