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2050-01-01
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DEPRESSIVE SYMPTOMS INCREASE THE RISK OF PROGRESSION TO DEMENTIA IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT: SYSTEMATIC REVIEW AND META-ANALYSIS.
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Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratorio de Investigação de Neurociência Clinica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratorio de Investigação de Neurociência Clinica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratorio de Investigação de Neurociência Clinica. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Departamento de Epidemiologia. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratorio de Investigação de Neurociência Clinica. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental. Belo Horizonte, MG, Brazil/Department of Psychiatry and Behavioral Sciences. University of Houston Health Science Center at Houston. Houston, TX, USA
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratorio de Investigação de Neurociência Clinica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratorio de Investigação de Neurociência Clinica. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Departamento de Epidemiologia. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratorio de Investigação de Neurociência Clinica. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental. Belo Horizonte, MG, Brazil/Department of Psychiatry and Behavioral Sciences. University of Houston Health Science Center at Houston. Houston, TX, USA
Abstract
Objective: There is a long-standing debate in the literature whether depressive symptoms increase the risk of dementia in older with mild cognitive impairment (MCI). We aim to conduct a meta-analysis of studies that evaluated the risk of dementia in subjects with MCI and depressive symptoms compared with subjects with MCI and no depressive symptoms. Methods: We calculated the relative risk of progression to dementia in subjects with MCI and depressive symptoms compared with subjects with MCI and no depressive symptoms using a generic inverse variance method with random effect models. Results: Eighteen studieswere includedin themeta-analysis,with a sample size of 10,861MCI subjects. The pooled relative risk of progressing to dementia was 1.28 CI95% [1.09–1.52] (p= 0.003) in the group of MCI subjects with depressive symptoms compared with the MCI subjects with no depressive symptoms. Discussion: Our results provide additional evidence that depressive symptoms determine an additive risk effect to the progression to dementia in subjects with MCI. The comorbidity between depression and cognitive impairment can be an intervention target for prevention of dementia in MCI subjects.
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