Canine mammary tumors are frequent in veterinary medical routine, leading to death due to high malignancy rate. Different chemotherapy modalities show large potential on treatment of mammary tumors, mainly improving quality of life. The objective of this report was present and discuss a conventional and metronomic chemotherapy in treatment of advanced stage of canine carcinoma in mixed tumor in femele dog with nine in canine female, nine years old, SRD, attended at the Veterinary Medicine Hospital of the Universidade Federal da Bahia. For this, were described in detail the data of clinical, anatomical and histological, Immune-histochemical and therapeutic therapeutic reports. Chemotherapy with carboplatin, at a dose of 300 mg/m² was not sufficiently effective on controlling metastatic progression, indicating the necessity of new protocols. Chemotherapy with carboplatin, at a dose of 300 mg/m² was not sufficiently effective on controlling metastatic progression, indicating the necessity of new protocols. So, metronomic chemotherapy has been shown excellent results, probably due to control of angiogenesis. Necroscopic and tomography findings were similars. This work also highlights the importance of a long time clinical monitoring of oncologic patients after surgery, in order to detect distant metastasis earlier.