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https://www.arca.fiocruz.br/handle/icict/26346
DIFFERENT PATTERNS OF DISEASE IN TWO INBRED MOUSE STRAINS INFECTED WITH A CLONE OF LEISHMANIA MEXICANA AMAZONENSIS
Leishmaniose murina
Leishmania
Parasite clones
L. mexicana
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Laboratorio de Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Laboratorio de Imunologia. Salvador, BA, Brasil
Abstract
We have infected BALB/c and C57BL/6 mice with a cloned Leishmania
mexicana amazonensis population, obtained from the "Maria" strain. Progres¬
sion of infection and histopathological examination confirmed the extreme
susceptibility of BALB/c mice and the resistant pattern ofthe C57 BL/6. Anti-
Leishmania antibody titers were higher in BALB/c than in C57BL/6 mice
through the period of infection. Tests of delayed type hypersensitivity reaction
with Leishmania antigens were positive in both strains in the beginning ofthe
infection, but were negative later on in BALB/c mice. Our results are similar to
those obtained with mixed parasite populations, and rule out the possibility of
selection among different parasite subpopulations as responsible for the diver¬
gent course of the disease exhibited by these two strains of mice.
Keywords in Portuguese
Leishmaniose cutâneaLeishmaniose murina
Leishmania
Parasite clones
L. mexicana
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