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https://www.arca.fiocruz.br/handle/icict/2615
TRANSMISSION OF STREPTOCOCCUS PNEUMONIAE IN AN URBAN SLUM COMMUNITY
Nasopharyngeal Carriage
pneumococcal conjugate vaccines
Antibiotic Resistance
Urban Slums
Vacinas Pneumocócicas
Portador Sadio
Técnica de Tipagem Bacteriana
DNA Bacteriano
Farmacorresistência Bacteriana
Vacinas Meningocócicas
Áreas de Pobreza
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Novartis Vaccines. Siena, Italia
Centers for Disease Control and Prevention. Streptococcus Laboratory. Atlanta, United States of America
Imperial College. Department of Infectious Disease Epidemiology. London, UK
School of Public Health, University of Califórnia. Division of Infectious Diseases. Berkeley, CA, United States of America
Novartis Vaccines. Siena, Italia
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Novartis Vaccines. Siena, Italia
Centers for Disease Control and Prevention. Streptococcus Laboratory. Atlanta, United States of America
Imperial College. Department of Infectious Disease Epidemiology. London, UK
School of Public Health, University of Califórnia. Division of Infectious Diseases. Berkeley, CA, United States of America
Novartis Vaccines. Siena, Italia
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Resumo em Inglês
Inhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries.We conducted a household survey of pneumococcal carriage among residents of a slum community in the city of Salvador, Brazil.Among 262 subjects, 95 (36%) were colonized with Streptococcus pneumoniae. Children <5 years of age (OR, 8.0; 95% CI, 3.5-18.6) and those who attended schools (OR, 2.7, 95% CI, 1.2-6.0) had significantly higher risk of being colonized. Of 94 isolates obtained from colonized individuals, 51% had serotypes included in the seven-valent pneumococcal conjugate vaccine. Overall, 10% (9 of 94 isolates) were nonsusceptible to penicillin and 28% (27 of 94 isolates) were resistant to cotrimoxazole. BOX-PCR, PFGE and MLST analyses found that 44% of the carriage isolates belonged to 14 distinct clonal groups. Strains of the same clonal group were isolated from multiple members of 9 out of the 39 study households. Nineteen carriage isolates had genotypes that were the same as those identified among 362 strains obtained from active surveillance for meningitis.The study's findings indicate that there is significant intra- and inter-household spread of S. pneumoniae in the slum community setting. However, a limited number of clones encountered during carriage among slum residents were found to cause invasive disease.
Palavras-chave em inglês
Streptococcus pneumoniaeNasopharyngeal Carriage
pneumococcal conjugate vaccines
Antibiotic Resistance
Urban Slums
DeCS
Streptococcus pneumoniaeVacinas Pneumocócicas
Portador Sadio
Técnica de Tipagem Bacteriana
DNA Bacteriano
Farmacorresistência Bacteriana
Vacinas Meningocócicas
Áreas de Pobreza
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