Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and control

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.

Abstract

In Brazil, malaria still remains a clinically important febrile syndrome for local populations and travelers, occurring mostly in the Amazon Basin. This review aims to report the main efforts employed to control this disease since the 1940s and the emergence of Plasmodium falciparum and Plasmodium vivax chemoresistance to chloroquine and sulphadoxine-pyrimethamine among other drugs. Additionally, in vivo, in vitro and molecular studies as well as malaria chemoresistance consequences on disease morbidity and policy treatment guidelines were commented.

Keywords in Portuguese

Plasmodium falciparum
Plasmodium vivax
malária
Brasil
quimiorresistência

Keywords

Plasmodium falciparum
Plasmodium vivax
malaria
chemoresistance
Brazil

Publisher

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz

Citation

GAMA, Bianca E. et al. Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and control. Mem Inst Oswaldo Cruz, v.106, Suppl. I, p.159-166, 2011.

ISSN

0074-0276

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25908

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