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https://www.arca.fiocruz.br/handle/icict/25823
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ArtigoDireito Autoral
Acesso restrito
Data de embargo
2030-01-01
Coleções
- IOC - Artigos de Periódicos [12708]
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INTRATHYMIC T CELL MIGRATION IS A MULTIVECTORIAL PROCESS UNDER A COMPLEX NEUROENDOCRINE CONTROL
Neuropilinas
Fibronectinas
Integrinas
Quimiocina
Semaforinas
Microambiente timo
Migração de timócitos
Thymic microenvironment
Laminin
Fibronectin
Integrins
Chemokines
semaphorins
Neuropilins
Savino, Wilson | Data do documento:
2010
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
Resumo em Inglês
The thymus is responsible for normal T cell development, a process that includes cell proliferation, death, migration, and T cell receptor gene rearrangements. Moreover, it depends on interactions between developing thymocytes and thymic microenvironmental cells. Along with differentiation, thymocytes migrate and such oriented movement is regulated by several molecular interactions, comprising extracellular matrix (ECM) elements and chemokines. We postulated that intrathymic T cell migration is a multivectorial process; each individual vector being represented by a given molecular interaction. In vivo and in vitro experiments revealed that migration of developing thymocytes, including the export of mature T cells, is upregulated by hormones, such as growth hormone and triiodothyronine, through the modulation of ECM-mediated interactions, associated or not with the chemokine CXCL12. Recent data revealed that molecular interactions typically found in the nervous system also affect intrathymic T cell migration. Semaphorin-3A, a soluble member of the semaphorin family, is involved in the control of human thymocyte migration, bearing a chemorepulsive role. Such an effect is partially due to its downregulatory effect upon the interactions mediated by fibronectin and laminin, as well as CXCL12. These data unravel a complex neuroendocrine control intrathymic T cell migration, involving both endocrine and paracrine molecular interactions.
Palavras-chave
LamininaNeuropilinas
Fibronectinas
Integrinas
Quimiocina
Semaforinas
Microambiente timo
Migração de timócitos
Palavras-chave em inglês
Thymocyte migrationThymic microenvironment
Laminin
Fibronectin
Integrins
Chemokines
semaphorins
Neuropilins
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