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https://www.arca.fiocruz.br/handle/icict/25019
RELATIONSHIP AMONG MOTHERS' GLYCEMIC LEVEL, PERIODONTITIS, AND BIRTH WEIGHT
Hemoglobina A, glicosilada
Infantil
Baixo peso ao nascer
Periodontite
Gravidez
Hemoglobin A
Glycosylated
Infant
Low birth weight
Periodontitis
Pregnancy
Autor(es)
Gomes Filho, Isaac Suzart
Pereira, Eliesita Costa
Cruz, Simone Seixas da
Adan, Luis Fernando Fernandes
Vianna, Maria Isabel Pereira
Soares, Johelle de Santana Passos
Trindade, Soraya Castro
Oliveira, Ernesto P
Oliveira, Michelle Teixeira
Cerqueira, Eneida de Moraes Marcilio
Pereira, Antonio Luis
Barreto, Maurício Lima
Seymour, Gregory John
Pereira, Eliesita Costa
Cruz, Simone Seixas da
Adan, Luis Fernando Fernandes
Vianna, Maria Isabel Pereira
Soares, Johelle de Santana Passos
Trindade, Soraya Castro
Oliveira, Ernesto P
Oliveira, Michelle Teixeira
Cerqueira, Eneida de Moraes Marcilio
Pereira, Antonio Luis
Barreto, Maurício Lima
Seymour, Gregory John
Afiliação
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil / Federal University of Recôncavo of Bahia. Santo Antonio de Jesus, BA, Brasil
Federal University of Bahia. Department of Medicine. Salvador, BA, Brasil
Federal University of Bahia. Department of Preventive Dentistry. Salvador, BA, Brasil
Feira de Santana State University. Department of Health. Salvador, BA, Brasil / Federal University of Bahia. Department of Preventive Dentistry. Salvador, BA, Brasil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Federal University of Bahia. Department of Pharmacy. Salvador, BA, Brazil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Federal University of Maranhão. Department of Dentistry. São Luís, MA, Brazil
Federal University of Bahia. Department of Public Health. Salvador, BA, Brazil
University of Otago. Sir John Walsh Research Institute. Dunedin, New Zealand
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil / Federal University of Recôncavo of Bahia. Santo Antonio de Jesus, BA, Brasil
Federal University of Bahia. Department of Medicine. Salvador, BA, Brasil
Federal University of Bahia. Department of Preventive Dentistry. Salvador, BA, Brasil
Feira de Santana State University. Department of Health. Salvador, BA, Brasil / Federal University of Bahia. Department of Preventive Dentistry. Salvador, BA, Brasil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Federal University of Bahia. Department of Pharmacy. Salvador, BA, Brazil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Feira de Santana State University. Department of Health. Salvador, BA, Brazil
Federal University of Maranhão. Department of Dentistry. São Luís, MA, Brazil
Federal University of Bahia. Department of Public Health. Salvador, BA, Brazil
University of Otago. Sir John Walsh Research Institute. Dunedin, New Zealand
Resumo em Inglês
The aim of this study is to determine the influence of glycemic level on the relationship between periodontitis and low birth weight (LBW). Methods: A case-control study was conducted with 372 females divided into cases (109 mothers of
newborns with birth weight <2,500 g) and controls (263 mothers of newborns with birth weight ‡2,500 g).
The birth weight of children was obtained from medical records, whereas information on sociodemographic,
lifestyle, and health characteristics of the participants was obtained through an interview. Glycated
hemoglobin (HbA1c) levels were measured, and probing depth, clinical attachment levels, and bleeding on
probing were used to determine the periodontal status. Results were analyzed using logistic regression.
Results: The likelihood of having children with LBW among the mothers with periodontitis was six times
greater than that observed among mothers without periodontitis (adjusted odds ratio [ORadjusted] = 6.02,
95% confidence interval [CI] = 2.47 to 15.17), even after adjustment. There was also a strong, statistically
significant relationship between periodontitis and LBW in both the normal glycemic–level group (HbA1c
levels <5.6%, unadjusted odds ratio [ORunadjusted] = 8.30, 95% CI = 3.56 to 19.35) and the high glycemic–level
group (HbA1c levels ‡5.6% and <6.5%, ORunadjusted = 5.73, 95% CI = 1.75 to 18.70). After adjustment for
confounders, the magnitude of the association continued to be strong in the normal glycemic–level group
(ORadjusted = 7.59, 95% CI = 2.7 to 24.28), an increase of 25% when compared to the main association measurement.
In those with high glycemic levels (ORadjusted = 4.03, 95% CI = 0.81 to 19.96), the OR decreased almost
50%, and the association lost statistical significance.
Conclusion: Periodontitis and glycemic levels appeared to have opposing influences on birth weight, with periodontitis
being associated with LBW and the magnitude of the association being altered depending on maternal
blood glucose level.
Palavras-chave
EpidemiologiaHemoglobina A, glicosilada
Infantil
Baixo peso ao nascer
Periodontite
Gravidez
Palavras-chave em inglês
EpidemiologyHemoglobin A
Glycosylated
Infant
Low birth weight
Periodontitis
Pregnancy
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