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EVALUATION OF PROGNOSTIC FACTORS AND SURVIVAL RATES IN MALIGNANT FELINE MAMMARY GLAND NEOPLASMS
Neoplasias mamárias
Metástase linfática
Prognostico
Animais
Author
Affilliation
Veterinary Sciences of the Sao Paulo State University. School of Agricultural. Department of Veterinary Clinic and Surgery. Jaboticabal, SP, Brazil / Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Faculty of Medicine. Department of Preventive and Social Medicine. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Veterinary Hospital. Veterinary School. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Faculty of Medicine. Department of Preventive and Social Medicine. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Veterinary Hospital. Veterinary School. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil
Abstract
The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Objectives The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms,
correlating them with overall survival (OS).
Methods Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female
cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone
and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and
vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic
factors with OS.
Results Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and
histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative
for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 (P = 0.046) and COX-2
(P = 0.007) was higher in metastases than in primary tumors. COX-2 (P = 0.089), HER-2 (P = 0.012) and histologic
grade (P = 0.080) were correlated with OS.
Conclusions and relevance The data suggest that inhibition of ovarian hormones and COX-2 may represent a
therapeutic option for malignant feline mammary gland neoplasms. When evaluating disease progression, COX-2
scores and Ki-67 index should be analyzed in primary tumors and metastases. histologic grade, HER-2 status and
COX-2 scores were found to have a direct influence on OS. Prognostic factors allow for a better understanding of
disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for
further studies on endocrine therapy and COX-2 inhibitors, which could influence OS.
Keywords in Portuguese
Neoplasia malignaNeoplasias mamárias
Metástase linfática
Prognostico
Animais
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