This paper conclud that assess the overall benefits of vaccination in high burden countries for dengue, long-term surveillance will require a robust, affordable, and user-friendly diagnostic algorithm to detect suspected dengue cases. After that Since a large variability in the results of the diagnostics may occur between different kits and laboratories worldwide, future phase IV studies of CYD-TDV vaccine effectiveness should use the proposed combined diagnostic testing with the same validated and standardized kits/ protocols and international guidelines when designing sentinel sites to ensure quality assurance and to enhance data sharing and comparability across regions.