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https://www.arca.fiocruz.br/handle/icict/24899
MATRIX METALLOPROTEINASE 9 PRODUCTION BY MONOCYTES IS ENHANCED BY TNF AND PARTICIPATES IN THE PATHOLOGY OF HUMAN CUTANEOUS LEISHMANIASIS
Monócitos
Fator de necrose tumoral alfa
Leucócitos mononucleares
Matrix Metalloproteinase 9
Humanos
Monocytes
Tumor Necrosis Factor-alpha
Leukocytes, Mononuclear
Matrix Metalloproteinase 9
Humans
Autor(es)
Afiliação
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brazil
University of Pennsylvania. Department of Pathobiology. Philadelphia, Pennsylvania, USA
University of Pennsylvania. Department of Pathobiology. Philadelphia, Pennsylvania, USA
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
University of Maryland. Department of Cell Biology and Molecular Genetics. Maryland, USA
University of Pennsylvania. Department of Pathobiology. Philadelphia, Pennsylvania, USA
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brazil
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brazil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brazil
University of Pennsylvania. Department of Pathobiology. Philadelphia, Pennsylvania, USA
University of Pennsylvania. Department of Pathobiology. Philadelphia, Pennsylvania, USA
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
University of Maryland. Department of Cell Biology and Molecular Genetics. Maryland, USA
University of Pennsylvania. Department of Pathobiology. Philadelphia, Pennsylvania, USA
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brazil
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brazil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Resumo em Inglês
Cutaneous leishmaniasis (CL) due to L.braziliensis infection is characterized by a strong inflammatory response with high levels of TNF and ulcer development. Less attention has been given to the role of mononuclear phagocytes to this process. Monocytes constitute a heterogeneous population subdivided into classical, intermediate and non-classical, and are known to migrate to inflammatory sites and secrete inflammatory mediators. TNF participates in the induction of matrix metalloproteinases (MMPs). MMP-9 is an enzyme that degrades basal membrane and its activity is controlled by the tissue inhibitor of metalloproteinase. Methods: Mononuclear cells were obtained from ex-vivo labeling sub-populations of monocytes and MMP-9, and the
frequency was determined by flow cytometry. Culture was performed during 72 hours, stimulating the cells with SLA, levels
of MMP-9 and TIMP-1 in the supernatants were determined by ELISA.
Results: We observed that cells from CL lesions secrete high amounts of MMP-9 when compared to healthy subjects.
Although MMP-9 was produced by monocytes, non-classical ones were the main source of this enzyme. We also observed
that TNF produced in high level during CL contributes to MMP-9 production.
Conclusions: These observations emphasize the role of monocytes, TNF and MMP-9 in the pathogenesis of L. braziliensis
infection.
Palavras-chave
Leishmaniose CutâneaMonócitos
Fator de necrose tumoral alfa
Leucócitos mononucleares
Matrix Metalloproteinase 9
Humanos
Palavras-chave em inglês
Leishmaniasis, CutaneousMonocytes
Tumor Necrosis Factor-alpha
Leukocytes, Mononuclear
Matrix Metalloproteinase 9
Humans
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