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GLYPICAN-3 DISTINGUISHES AGGRESSIVE FROM NON-AGGRESSIVE ODONTOGENIC TUMORS: A PRELIMINARY STUDY
Glypican-3
Tumor odontogênico queratocístico
Ttumores odontogênicos
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Department of Public Health. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil
Federal University of Rio Grande do Sul. School of Dentistry. Department of Oral Pathology. Porto Alegre, RGS, Brazil
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, Brazil
University of São Paulo. School of Dentistry. Department of Oral Pathology. São Paulo, SP, Brazil
Federal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, Brazil
University of Catania. Department of Medical and Surgical Sciences. Catania, Italy
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Department of Public Health. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil
Federal University of Rio Grande do Sul. School of Dentistry. Department of Oral Pathology. Porto Alegre, RGS, Brazil
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, Brazil
University of São Paulo. School of Dentistry. Department of Oral Pathology. São Paulo, SP, Brazil
Federal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, Brazil
University of Catania. Department of Medical and Surgical Sciences. Catania, Italy
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, Brazil
Resumen en ingles
Glypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors. METHODS: Fifty-nine cases of tumors were divided into
aggressive odontogenic tumors (20 solid ameloblastomas,
four unicystic ameloblastoma, 28 KOTs including
five associated with Gorlin–Goltz syndrome) and nonaggressive
odontogenic tumors (five adenomatoid odontogenic
tumors and two calcifying cystic odontogenic
tumors) and analyzed for glypican-3 using immunohistochemistry.
RESULTS: Glypican-3 was observed in seven solid
ameloblastoma and eighteen keratocystic odontogenic
tumors including three of the five syndromic cases,
but there was no significant difference between syndromic
and sporadic cases (P > 0.05; Fisher’s exact Test). All
cases of unicystic ameloblastoma (n = 4), adenomatoid
odontogenic tumor (n = 5), and calcifying cystic odontogenic
tumor (n = 2) were negative.
CONCLUSIONS: This provided insights into the presence
of glypican-3 in odontogenic tumors. This protein
distinguished aggressive from non-aggressive odontogenic
tumors.
Palabras clave en portugues
AmeloblastomaGlypican-3
Tumor odontogênico queratocístico
Ttumores odontogênicos
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