Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/23560
Type
Papers presented at eventsCopyright
Open access
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
Metadata
Show full item record
IN VITRO AND IN VIVO EVALUATION OF ANTI-TRYPANOSOMA CRUZI ACTIVITY OF DERIVATES OF VITAMIN K
Doença de Chagas
Quimioterapia
Vitamina K
Microscopia eletrônica
Humanos
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Federal University of Bahia. Department of Biophysics. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Federal University of Bahia. Department of Biophysics. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil
Abstract
About 10 million people worldwide are infected by Trypanosoma cruzi, etiologic agent of Chagas disease.
The absence of effective trypanocidal chemotherapy reflects the need for constant research in this area.
Some compounds such as naphtoquinones can reduce trypanothione reductase (TR), specific enzyme of
trypanossomatids, which controls cellular oxidative stress. Inhibition of TR favors an oxidative process and
death of the parasite. In this work, we investigate the trypanocidal potential of phytomenadione (K1) and
menadione (K3), both vitamins K derived from naphthoquinones.
Keywords in Portuguese
Trypanosoma cruziDoença de Chagas
Quimioterapia
Vitamina K
Microscopia eletrônica
Humanos
Share