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SIMPLAGRIN, A PLATELET AGGREGATION INHIBITOR FROM SIMULIUM NIGRIMANUM SALIVARY GLANDS SPECIFICALLY BINDS TO THE VON WILLEBRAND FACTOR RECEPTOR IN COLLAGEN AND INHIBITS CAROTID THROMBUS FORMATION IN VIVO
Chagas, Andrezza C. et al. | Date Issued: 2014
Author
Chagas, Andrezza C.
McPhie, Peter
San, Hong
Narum, David
Reiter, Karine
Tokomasu, Fuyuki
Brayner, Fabio A.
Alves, Luiz C.
Ribeiro, José M. C.
Calvo, Eric
Affilliation
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
Physical and Biochemistry Section, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Animal Surgery and Resources Core, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America.
Laboratory of Malaria Immunology and Vaccinology, NIAID, NIH, Bethesda, Maryland, United States of America.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Abstract
Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to efficient blood feeding. Here we report the first inhibitor of collagen-induced platelet aggregation derived from the salivary glands of a black fly (Simulium nigrimanum), named Simplagrin.
Keywords in Portuguese
glândulas salivares
mosquitos
moscas negras
Inibidores
 
Keywords
Salivary Glands
mosquitoes
black flies
Inibidores
 
DeCS
Proteínas de Insetos
metabolismo
Inibidores da Agregação de Plaquetas
metabolismo
Glicoproteínas da Membrana de Plaquetas
metabolismo
Glândulas Salivares
química
Simuliidae
metabolismo
Sequência de Aminoácidos
Animais
Trombose das Artérias Carótidas
prevenção & controle
Feminino
Células HEK293
Camundongos Endogâmicos BALB C
Humanos
Camundongos Endogâmicos C57BL
Dados de Sequência Molecular
Adesividade Plaquetária
Agregação Plaquetária
Ligação Proteica Estrutura
Terciária de Proteína
 
Citation
CHAGAS, A. C. et al. Simplagrin, a Platelet Aggregation Inhibitor from Simulium nigrimanum Salivary Glands Specifically Binds to the Von Willebrand Factor Receptor in Collagen and Inhibits Carotid Thrombus Formation In Vivo. PLoS Neglected Tropical Diseases, v. 8, n. 6, p. e2947, 12 jun. 2014.
DOI
10.1371/journal.pntd.0002947
ISSN
1935-2735