Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/23125
Type
ArticleCopyright
Open access
Sustainable Development Goals
05 Igualdade de gêneroCollections
- INI - Artigos de Periódicos [3488]
- IOC - Artigos de Periódicos [12747]
Metadata
Show full item record
CLAUDIN-1 EXPRESSION IN HIV/HPV CO-INFECTED ANAL INTRA-EPITHELIAL NEOPLASIA
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
University of California. Department of Medicine. San Francisco, CA, USA.
Abstract
Background: Claudin-1 expression is poorly characterized in anal intraepithelial neoplasia (AIN) from HIVpositive individuals. Aim: To investigate claudin-1 in situ expression in HPV-positive AIN lesions from HIV-positive individuals compared with non-dysplastic anal tissues. Materials and Methods: By means of immunofluorescence microscopy, claudin-1 was analyzed in 46 anal tissues: 18 AIN1; 14 AIN2/3 and 14 non-dysplastic specimens. Results: A higher proportion of cells with overexpression of claudin-1 were found in HIV-positive AIN lesions compared with controls. Overexpression of claudin-1 was most evident in AIN 2/3 lesions. HPV16 was detected in 21.8% anal specimens and HPV18 in 3.1%. A great diversity of 18 low-risk HPV types were detected, 40% of AIN specimens had multiple HPV types. Conclusions: Our data show that there is an over-expression of claudin-1 in HIV-positive AIN lesions compared with non-dysplastic anal biopsies. A high prevalence of HPV16 and diversity of HPV types was detected. The overexpression of claudin-1 in HIV-positive AIN specimens may play a role on the development of anal cancer, however further studies should be performed to better understand the role of claudin-1 in AIN and anal cancer development in the HIV-positive individuals.
Share