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https://www.arca.fiocruz.br/handle/icict/23031
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2030-01-01
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- IOC - Artigos de Periódicos [12642]
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LIPID BODIES IN INFLAMMATORY CELLS: STRUCTURE, FUNCTION, AND CURRENT IMAGING TECHNIQUES
Leucócitos
Macrófagos
Inflamação
immune immunity
eicosanóides
microscopia eletrônica
microscopia de fluorescência
técnicas de imagem
proteína relacionada à diferenciação adiposa
leokocytes
macrophages
inflammation
immune immunity
eicosanoids
adipose differentiation-related protein
electron microscopy
fluorescence microscopy
imaging techniques
Author
Affilliation
Universidade Federal de Juiz de Fora. Departamento de Biologia. Laboratório de Biologia Celular. Juiz de Fora, MG, Brasi / Harvard Medical School. Beth Israel Deaconess Medical Center. Departmemt of Medicine, Pathology. Boston, MA, USA.
Universidade Federal de Juiz de Fora. Departamento de Biologia. Juiz de Fora, MG, Brasil.
Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Departament of Pathology. Boston, MA, USA.
Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.
Universidade Federal de Juiz de Fora. Departamento de Biologia. Juiz de Fora, MG, Brasil.
Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Departament of Pathology. Boston, MA, USA.
Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.
Abstract
Lipid bodies (LBs), also known as lipid droplets, have increasingly been recognized as functionally active organelles linked to diverse biological functions and human diseases. These organelles are actively formed in vivo within cells from the immune system, such as macrophages, neutrophils, and eosinophils, in response to different inflammatory conditions and are sites for synthesis and storage of inflammatory mediators. In this review, the authors discuss structural and functional aspects of LBs and current imaging techniques to visualize these organelles in cells engaged in inflammatory processes, including infectious diseases. The dynamic morphological aspects of LBs in leukocytes as inducible, newly formable organelles, elicitable in response to stimuli that lead to cellular activation, contribute to the evolving understanding of LBs as organelles that are critical regulators of different inflammatory diseases, key markers of leukocyte activation, and attractive targets for novel anti-inflammatory therapies.
Keywords in Portuguese
gota de lípidoLeucócitos
Macrófagos
Inflamação
immune immunity
eicosanóides
microscopia eletrônica
microscopia de fluorescência
técnicas de imagem
proteína relacionada à diferenciação adiposa
Keywords
lipid dropletleokocytes
macrophages
inflammation
immune immunity
eicosanoids
adipose differentiation-related protein
electron microscopy
fluorescence microscopy
imaging techniques
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