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THE TRANSLATION INITIATION COMPLEX EIF3 IN TRYPANOSOMATIDS AND OTHER PATHOGENIC EXCAVATES--IDENTIFICATION OF CONSERVED AND DIVERGENT FEATURES BASED ON ORTHOLOGUE ANALYSIS
Biosíntesis de Proteínas
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The initiation of translation in eukaryotes is supported by the action of several eukaryotic Initiation Factors (eIFs). The largest of these is eIF3, comprising of up to thirteen polypeptides (eIF3a through eIF3m), involved in multiple stages of the initiation process. eIF3 has been better characterized from model organisms, but is poorly known from more diverged groups, including unicellular lineages represented by known human pathogens. These include the trypanosomatids (Trypanosoma and Leishmania) and other protists belonging to the taxonomic supergroup Excavata (Trichomonas and Giardia sp.).
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TrypanosomaPalabras clave
Factor 3 Procariótico de IniciaciónBiosíntesis de Proteínas
Infecciones por Protozoos
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