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https://www.arca.fiocruz.br/handle/icict/21095
EFFECTIVENESS OF THE FIRST DOSE OF BCG AGAINST TUBERCULOSIS AMONG HIV-INFECTED, PREDOMINANTLY IMMUNODEFICIENT CHILDREN
BCG Vaccine
Case-Control Studies
Child
Child, Preschool
Coinfection
Female
HIV Infections
Humans
Infant
Male
Mycobacterium bovis
Tuberculosis
Vaccination
administração & dosagem
Coinfecção
imunologia
microbiologia
prevenção & controle
Infecções por HIV
Tuberculose
Humanos
Adolescente
Estudos de Casos e Controles
Criança
Pré-escolar
Feminino
Masculino
Lactente
Mycobacterium bovis
Tuberculose
Vacinação
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Resumo em Inglês
The objective of this study was to estimate the protective effect of Bacille Calmette-Guérin (BCG) vaccine against tuberculosis among (predominantly immunodeficient) HIV-infected children in Angola. A hospital-based case-control study was conducted with 230 cases, children coinfected with tuberculosis, and 672 controls, HIV-infected children from the same hospital, aged 18 months to 13 years. The presence of a vaccination scar was taken as a proxy marker for BCG vaccination. The crude effectiveness was 8% (95% CI: -26 to 32) and the adjusted effectiveness was 30% (95% CI: -75 to 72). The present study suggests that BCG does not have a protective effect against tuberculosis among immunodeficient HIV-infected children. Since BCG is no longer given to HIV-infected children, the study may not be replicated. Accepting that these findings should be considered with caution, they are nonetheless likely to be the last estimate of BCG efficacy in a sufficiently powered study.
Palavras-chave em inglês
AdolescentBCG Vaccine
Case-Control Studies
Child
Child, Preschool
Coinfection
Female
HIV Infections
Humans
Infant
Male
Mycobacterium bovis
Tuberculosis
Vaccination
DeCS
Vacina BCGadministração & dosagem
Coinfecção
imunologia
microbiologia
prevenção & controle
Infecções por HIV
Tuberculose
Humanos
Adolescente
Estudos de Casos e Controles
Criança
Pré-escolar
Feminino
Masculino
Lactente
Mycobacterium bovis
Tuberculose
Vacinação
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