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https://www.arca.fiocruz.br/handle/icict/20957
CD8+ GAMMA-DELTA TCR+ AND CD4+ T CELLS PRODUCE IFN-γ AT 5-7 DAYS AFTER YELLOW FEVER VACCINATION IN INDIAN RHESUS MACAQUES, BEFORE THE INDUCTION OF CLASSICAL ANTIGEN-SPECIFIC T CELL RESPONSES
Vacina
respostas de células T específicas
Antígenos
Macacos rhesus indianos
IFN-γ
Rhesus model
Indian rhesus macaques
antigen-specific T cell responses
Author
Affilliation
Fundação Oswaldo Cruz. Bio-Manguinhos. Vice-Diretoria de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
Fundação Oswaldo Cruz. Bio-Manguinhos. Vice-Diretoria de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
Fundação Oswaldo Cruz. Bio-Manguinhos. Vice-Diretoria de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology. Laboratory Medicine. Madison, WI, USA.
Abstract
The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8(+) and CD4(+) T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8(+) gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4(+) T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.
Keywords in Portuguese
Febre AmarelaVacina
respostas de células T específicas
Antígenos
Macacos rhesus indianos
Keywords
Yellow Fever vaccineIFN-γ
Rhesus model
Indian rhesus macaques
antigen-specific T cell responses
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