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AN INVESTIGATION OF THE CLONALITY OF HUMAN AUTOIMMUNE THYROGLOBULIN ANTIBODIES AND THEIR LIGHT CHAINS
Afiliación
Middlesex Hospital Medical School. Department of Immunology. London, USA
Middlesex Hospital Medical School. Department of Immunology. London, USA
Middlesex Hospital Medical School. Department of Immunology. London, USA
Middlesex Hospital Medical School. Department of Immunology. London, USA
Middlesex Hospital Medical School. Department of Immunology. London, USA
Resumen en ingles
Thyroglobulin antibodies in the sera from 31 patients with a variety of disorders were
studied by isoelectric focusing. Only one gave a spectrotype indicative of a monoclonal
response, the other 30 giving spectrotypes characteristic of polyclonal responses. There
was evidence of clonal dominance in some of the sera and each gave a different
spectrotype. Light chains were prepared from five thyroglobulin antibodies purified by
affinity chromatography. There was no restriction in the spectrotypes when compared
with light chains prepared from normal immunoglobulin.
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