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https://www.arca.fiocruz.br/handle/icict/20525
A MINIMUM SET OF ANCESTRY INFORMATIVE MARKERS FOR DETERMINING ADMIXTURE PROPORTIONS IN A MIXED AMERICAN POPULATION: THE BRAZILIAN SET
Grupo de ascendência africana continental
Grupo de Ancestralidade no Continente Europeu
Marcadores genéticos
Genoma humano
Humanos
Brasil
Group of African Continental Ancestry
European Continental Ancestry Group
Genetic Markers
Genome Human
Humans
Brazil
Autor(es)
Santos, Hadassa Campos
Horimoto, Andréa Roseli Vancan Russo
Santos, Eduardo Martín Tarazona
Soares, Fernanda Rodrigues
Barreto, Maurício Lima
Horta, Bernardo Lessa
Costa, Maria Fernanda Furtado de Lima
Gouveia, Mateus Henrique
Machado, Moara
Silva, Thiago Magalhães da
Sanches, José Maurício
Esteban, Nubia
Magalhães, Wagner Carlos Santos
Rodrigues, Maíra Ribeiro
Kehdy, Fernanda de Souza Gomes
Pereira, Alexandre da Costa
The Brazilian EPIGEN Project Consortium
Horimoto, Andréa Roseli Vancan Russo
Santos, Eduardo Martín Tarazona
Soares, Fernanda Rodrigues
Barreto, Maurício Lima
Horta, Bernardo Lessa
Costa, Maria Fernanda Furtado de Lima
Gouveia, Mateus Henrique
Machado, Moara
Silva, Thiago Magalhães da
Sanches, José Maurício
Esteban, Nubia
Magalhães, Wagner Carlos Santos
Rodrigues, Maíra Ribeiro
Kehdy, Fernanda de Souza Gomes
Pereira, Alexandre da Costa
The Brazilian EPIGEN Project Consortium
Afiliação
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Bahia. Institute of Public Health. Salvador, BA, Brazil
Federal University of Pelotas. Porto Alegre, RGS, Brazil
Oswaldo Cruz Foundation. Rene Rachou Research Institute. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Bahia. Institute of Public Health. Salvador, BA, Brazil
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
The Brazilian EPIGEN Project Consortium
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Bahia. Institute of Public Health. Salvador, BA, Brazil
Federal University of Pelotas. Porto Alegre, RGS, Brazil
Oswaldo Cruz Foundation. Rene Rachou Research Institute. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Bahia. Institute of Public Health. Salvador, BA, Brazil
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, Brazil
Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, Brazil
The Brazilian EPIGEN Project Consortium
Resumo em Inglês
The Brazilian population is considered to be highly admixed. The main contributing ancestral populations were European and African, with Amerindians contributing to a lesser extent. The aims of this study were to provide a resource for determining and quantifying individual continental ancestry using the smallest number of SNPs possible, thus allowing for a cost- and time-efficient strategy for genomic ancestry determination. We identified and validated a minimum set of 192 ancestry informative markers (AIMs) for the genetic ancestry determination of Brazilian populations. These markers were selected on the basis of their distribution throughout the human genome, and their capacity of being genotyped on widely available commercial platforms. We analyzed genotyping data from 6487 individuals belonging to three Brazilian cohorts. Estimates of individual admixture using this 192 AIM panels were highly correlated with estimates using ~370 000 genome-wide SNPs: 91%, 92%, and 74% of, respectively, African, European, and Native American ancestry components. Besides that, 192 AIMs are well distributed among populations from these ancestral continents, allowing greater freedom in future studies with this panel regarding the choice of reference populations. We also observed that genetic ancestry inferred by AIMs provides similar association results to the one obtained using ancestry inferred by genomic data (370 K SNPs) in a simple regression model with rs1426654, related to skin pigmentation, genotypes as dependent variable. In conclusion, these markers can be used to identify and accurately quantify ancestry of Latin Americans or US Hispanics/Latino individuals, in particular in the context of fine-mapping strategies that require the quantification of continental ancestry in thousands of individuals.
Palavras-chave
PopulaçãoGrupo de ascendência africana continental
Grupo de Ancestralidade no Continente Europeu
Marcadores genéticos
Genoma humano
Humanos
Brasil
Palavras-chave em inglês
PopulationGroup of African Continental Ancestry
European Continental Ancestry Group
Genetic Markers
Genome Human
Humans
Brazil
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