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https://www.arca.fiocruz.br/handle/icict/20478
EFFECTS OF MATERNAL GEOHELMINTH INFECTIONS ON ALLERGY IN EARLY CHILDHOOD
Autor(es)
Afiliação
Laboratorio de Investigaciones FEPIS. Quininde / Pontificia Universidad Catolica del Ecuador. Centro de Investigacion en Enfermedades Infecciosas. Quito, Ecuador / Institutes of Infection and Immunity. Quito, Ecuador
Laboratorio de Investigaciones FEPIS. Quininde
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Laboratorio de Investigaciones FEPIS. Quininde
Laboratorio de Investigaciones FEPIS. Quininde
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, WC
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
St George’s University of London. Public Health Sciences. London, WC
Laboratorio de Investigaciones FEPIS. Quininde
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Laboratorio de Investigaciones FEPIS. Quininde
Laboratorio de Investigaciones FEPIS. Quininde
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, WC
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
St George’s University of London. Public Health Sciences. London, WC
Resumo em Inglês
Maternal geohelminth infections during pregnancy may protect against allergy development in childhood. Objective: We sought to investigate the effect of maternal
geohelminths on the development of eczema, wheeze, and atopy
during the first 3 years of life.
Methods: A cohort of 2404 neonates was followed to 3 years of
age in a rural district in coastal Ecuador. Data on wheeze and
eczema were collected by means of questionnaire and physical
examination at 13, 24, and 36 months of age. Atopy was
measured based on skin prick test (SPT) reactivity to 9 allergens
at 36 months. Maternal stool samples were examined for
geohelminths by microscopy. Data on potential confounders was
collected after birth by questionnaire.
Results: Geohelminths were observed in 45.9% of mothers.
Eczema and wheeze were reported for 17.7% and 25.9%,
respectively, of 2069 (86.1%) children with complete follow-up
to 3 years, and allergen SPT reactivity to any allergen was
present in 17.2% and to house dust mite in 8.7%. Maternal
geohelminth infections were not significantly associated with
eczema (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61),
wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT
reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61-
1.01). In subgroup analyses maternal geohelminths were
associated with a significantly reduced risk of SPT reactivity to
mite and other perennial allergens, and maternal ascariasis was
associated with an increased risk of eczema and reduced risk of
SPT reactivity to all allergens.
Conclusion: Our data do not support a protective effect of
maternal infections with geohelminth parasites during
pregnancy against the development of eczema and wheeze in
early childhood, although there was evidence in subgroup
analyses for a reduction in SPT reactivity to house dust
mites and perennial allergens.
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