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DESIGN, SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF PHTHALIMIDES ENDOWED WITH DUAL ANTIPROLIFERATIVE AND IMMUNOMODULATORY ACTIVITIES
Thiosemicarbazone
Thiazole
Thiazolidinone
Antiproliferativa
Imunosupressora
Thiosemicarbazone
Thiazole
Thiazolidinone
Antiproliferative
Immunosuppressive
Autor
Cardoso, Marcos Veríssimo de Oliveira
Moreira, Diogo Rodrigo Magalhães
Oliveira Filho, Gevanio Bezerra
Cavalcanti, Suellen Melo Tiburcio
Coelho, Lucas Cunha Duarte
Espíndola, José Wanderlan Pontes
Gonzalez, Laura Rubio
Rabello, Marcelo Montenegro
Hernandes, Marcelo Zaldini
Ferreira, Paulo Michel Pinheiro
Pessoa, Cláudia
Simone, Carlos Alberto de
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
Leite, Ana Cristina Lima
Moreira, Diogo Rodrigo Magalhães
Oliveira Filho, Gevanio Bezerra
Cavalcanti, Suellen Melo Tiburcio
Coelho, Lucas Cunha Duarte
Espíndola, José Wanderlan Pontes
Gonzalez, Laura Rubio
Rabello, Marcelo Montenegro
Hernandes, Marcelo Zaldini
Ferreira, Paulo Michel Pinheiro
Pessoa, Cláudia
Simone, Carlos Alberto de
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
Leite, Ana Cristina Lima
Afiliación
Múltipla - ver em Notas
Resumen en ingles
The present work reports the synthesis and evaluation of the antitumour and immunomodulatory properties of new phthalimides derivatives designed to explore molecular hybridization and bioisosterism approaches between thalidomide, thiosemicarbazone, thiazolidinone and thiazole series. Twenty-seven new molecules were assessed for their immunosuppressive effect toward TNFα, IFNγ, IL-2 and IL-6 production and antiproliferative activity. The best activity profile was observed for the (6a-f) series, which presents phthalyl and thiazolidinone groups.
Palabras clave en portugues
FtalimidasThiosemicarbazone
Thiazole
Thiazolidinone
Antiproliferativa
Imunosupressora
Palabras clave en ingles
PhthalimideThiosemicarbazone
Thiazole
Thiazolidinone
Antiproliferative
Immunosuppressive
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