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https://www.arca.fiocruz.br/handle/icict/19513
INTERFERON-GAMMA LEVELS DURING THE COURSE OF TRYPANOSOMA CRUZI INFECTION OF CALOMYS CALLOSU$ (RODENTIA-CRICETIDAE) AND SWISS MICE
Autor(es)
Afiliação
Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil
Instituto Butantan. Laboratório de Imanunologia Viral. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Instituto Butantan. Laboratório de Imanunologia Viral. São Paulo, SP, Brasil
Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil
Instituto Butantan. Laboratório de Imanunologia Viral. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Instituto Butantan. Laboratório de Imanunologia Viral. São Paulo, SP, Brasil
Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil
Resumo em Inglês
Serum levels of interferon-gamma (IFN-y)
were evaluated in Calomys callosus and Swiss mice during
the course of infection by four strains of Trypanosoma
cruzi. All strains stimulated the production of this interleukine;
however, the timing of its onset and permanence
varied among strains and between the two animal
models. When chronically infected animals with no detectable
serum IFN-y were challenged with the homologous
strain, they produced quantities comparable with
those obtained during the acute phase of infection. In C.
callosus there was a correlation between H202 liberation
by peritoneal macrophages and serum IFN-y levels,
whereas no such correlation was found in mice. C. callosus
had a higher capacity to heal histopathological lesions,
whereas lesions in mice were progressive, The results
obtained suggest that C. callosus develops welladapted
immune mechanisms that may be important for
its role as a reservoir of T. cruzi.
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