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https://www.arca.fiocruz.br/handle/icict/19473
CANINE β-DEFENSIN-1 (CBD1) GENE AS A POSSIBLE MARKER FOR LEISHMANIA INFANTUM INFECTION IN DOGS
Polimorfismos de nucleotídeo único
Leishmaniose canina
Cães
Leishmaniose Visceral / veterinária
Reação em Cadeia da Polimerase em Tempo Real
beta-defensens / genética
Leishmania infantum / isolamento & purificação
Leishmaniose Visceral / genética
Author
Affilliation
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
University of Bari. Department of Veterinary Medicine. Valenzano, Bari, Italy.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
University of Bari. Department of Veterinary Medicine. Valenzano, Bari, Italy / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
University of Bari. Department of Veterinary Medicine. Valenzano, Bari, Italy.
Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
University of Bari. Department of Veterinary Medicine. Valenzano, Bari, Italy / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Abstract
Canine leishmaniasis caused by Leishmania infantum is a parasitic disease of great veterinary significance. Some dogs infected by L. infantum may mount a strong cellular immune response and clear the infection, while others may respond with exaggerated antibody production against the parasite and develop an overt disease, which may be fatal, if left untreated. The initial factors triggering the polarization of the immune response towards a predominantly T-helper 1 or T-helper 2 cytokines, as well as the markers of resistance and susceptibility to L. infantum infection and disease development in dogs, are not fully understood. Herein, we assessed the association between single nucleotide polymorphisms (SNPs) in the canine β-defensin-1 (CBD1) gene and the infection by L. infantum in two dog populations from Brazil (Sobral in Ceará State and São Raimundo Nonato in Piauí State) and one dog population from Italy.
Keywords in Portuguese
Gene β-defensina-1 caninaPolimorfismos de nucleotídeo único
Leishmaniose canina
Cães
DeCS
Doenças do Cão / genéticaLeishmaniose Visceral / veterinária
Reação em Cadeia da Polimerase em Tempo Real
beta-defensens / genética
Leishmania infantum / isolamento & purificação
Leishmaniose Visceral / genética
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