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2030-01-01
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- IOC - Artigos de Periódicos [12708]
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DEVELOPING T-CELL MIGRATION: ROLE OF SEMAPHORINS AND EPHRINS
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Genética. Curitiba. PR, Brasil / Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain.
Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Complutense University. Department of Cell Biology, Faculty of Biology. Madrid, Spain / Instituto Nacional de CÂncer. Centro de Pesquisa. Programa de Oncologia e Hematologia Pediátrica. Rio de Janeiro, RJ, Brasil.
Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain.
Complutense University. Center of Cytometry and Fluorescence Microscopy. Madrid, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain / Complutense University. Center of Cytometry and Fluorescence Microscopy. Madrid, Spain..
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Genética. Curitiba. PR, Brasil / Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain.
Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Complutense University. Department of Cell Biology, Faculty of Biology. Madrid, Spain / Instituto Nacional de CÂncer. Centro de Pesquisa. Programa de Oncologia e Hematologia Pediátrica. Rio de Janeiro, RJ, Brasil.
Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain.
Complutense University. Center of Cytometry and Fluorescence Microscopy. Madrid, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
Complutense University. Faculty of Biology. Department of Cell Biology, Madrid, Spain / Complutense University. Center of Cytometry and Fluorescence Microscopy. Madrid, Spain..
Abstract
Cell migration is a crucial event for normal T-cell development, and various ligand/receptor pairs have been implicated. Most of them, including chemokines and extracellular matrix proteins, have attractant properties on thymocytes. We discuss herein two further groups of ligand/receptor pairs, semaphorins/neuropilins and ephs/ephrins, which are constitutively expressed by thymocytes and thymic microenvironmental cells. Evidence shows that the corresponding interactions are relevant for developing T-cell migration, including the entry of bone marrow progenitor cells, migration of CD4/CD8-defined thymocyte subpopulations triggered by chemokines and/or extracellular matrix proteins, and thymocyte export. Conceptually, the data summarized here show that thymocyte migration results from a complex network of molecular interactions, which generate not only attraction, but also repulsion of migrating T-cell precursors.
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