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ArtigoDireito Autoral
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- IOC - Artigos de Periódicos [12642]
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ENHANCED T CELL ACTIVATION IN PLASMODIUM FALCIPARUM MALARIA-INFECTED HUMAN IMMUNODEFICIENCY VIRUS-1 PATIENTS FROM MOZAMBIQUE
cellular activation
Plasmodium
co-infection
CD4+ T cells
Mozambique
Afiliação
Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Moçambique / Hospital Central de maputo. Laboratório de Biologia Molecular. Maputo, Moçambique.
Resumo em Inglês
Human immunodeficiency virus (HIV)-1 infection has an important impact on malaria. Plasmodium falciparum and HIV-1 co-infected patients (Pf/HIV) present with a high degree of anaemia, enhanced parasitaemia and decreased CD4+ T cell counts, which increase the risk of developing severe malaria. In addition, infection with either Pf or HIV-1 alone causes extensive immune activation. Our hypothesis was that lymphocyte activation is potentiated in Pf/HIV co-infected patients, consequently worsening their immunosuppressed state. To test this hypothesis, 22 Pf/HIV patients, 34 malaria patients, 29 HIV/AIDS patients and 10 healthy controls without malaria or HIV/acquired immune deficiency syndrome (AIDS) from Maputo/Mozambique were recruited for this study. As expected, anaemia was most prevalent in the Pf/HIV group. A significant variation in parasite density was observed in the Pf/HIV co-infected group (110-75,000 parasites/μL), although the median values were similar to those of the malaria only patients. The CD4+ T cell counts were significantly lower in the Pf/HIV group than in the HIV/AIDS only or malaria only patients. Lymphocyte activation was evaluated by the percentage of activation-associated molecules [CD38 expression on CD8+ and human leukocyte antigen-DR expression on CD3+ T cells]. The highest CD38 expression was detected in the Pf/HIV co-infected patients (median = 78.2%). The malaria only (median = 50%) and HIV/AIDS only (median = 52%) patients also exhibited elevated levels of these molecules, although the values were lower than those of the Pf/HIV co-infected cases. Our findings suggest that enhanced T-cell activation in co-infected patients can worsen the immune response to both diseases.
Palavras-chave em inglês
malaria/HIV-AIDScellular activation
Plasmodium
co-infection
CD4+ T cells
Mozambique
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