The importance of CD8 infiltration for cancer prognosis has been underscored lately by the increased use of checkpoint inhibitors in patients with invasive tumors. The objective of this study was to determine if CD8 infiltration and the expression of two key checkpoint proteins, PD-L1 and PD-L2, varied between early stage (FIGO IA-IIA) and advanced stage (FIGO IIB-IVA) cervical cancer. A tissue micro-array with 61 cervical specimens was analyzed through immunohistochemistry for PD-L1, PD-L2 and CD8 using CD1a (antigen presenting cells) as an internal control. Infiltration of both CD8 and CD1a was evident in control, benign tissues that showed little to no PD-L1 and PD-L2 reactivity. In samples of invasive cervical cancers, there was a three-fold increase in the number of CD8 cells with an increase in the expression of both PD-L1 and PD-L2 (P<0.001 for each vs. control). A slight decrease in the number of CD1a cells was observed in malignant tissues compared to controls. No significant difference was evident for the infiltration of CD8+ cells or the expression of either PD-L1 and PD-L2 between the samples of early stage (FIGO IA-IIA) and advanced stage (FIGO IIB-IVA) cancers. Cytotoxic T cell infiltration and expression of two of its key checkpoint proteins (PD-L1 and PD-L2) remained constant as cervical cancers advance from early stage to late stage tumors. This suggests that the immune response may be equivalent in early and late stage cervical cancers.