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ASSOCIATION OF SICCA SYNDROME WITH PROVIRAL LOAD AND PROINFLAMMATORY CYTOKINES IN HTLV-1 INFECTION
Vírus linfotrópico T humano 1
Regulação da expressão genética
Humanos
Interleucina-10
Proviruses
Síndrome de Sjogren
Necrose Tumoral
Carga Viral
T-lymphotropic virus 1 Human
Gene Expression Regulation
Human
Interleukin-10
Proviruses
Sjogren's Syndrome
Tumor Necrosis
Viral Load
Autor
Afiliación
Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia. Department of Otolaryngology. Salvador, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases (CNPq/MCT). Salvador, BA, Brazil / State University of Feira de Santana (UEFS). Department of Biological Sciences, Feira de Santana, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil
Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Department of Otolaryngology. Salvador, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases (CNPq/MCT). Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases (CNPq/MCT). Salvador, BA, Brazil / State University of Feira de Santana (UEFS). Department of Biological Sciences, Feira de Santana, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil
Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Department of Otolaryngology. Salvador, BA, Brazil
Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia. Professor Edgard Santos University Hospital. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases (CNPq/MCT). Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Resumen en ingles
The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-α and IFN-γ was higher in the group with sicca syndrome (P < 0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome. However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.
Palabras clave en portugues
Infecções por HTLV-IVírus linfotrópico T humano 1
Regulação da expressão genética
Humanos
Interleucina-10
Proviruses
Síndrome de Sjogren
Necrose Tumoral
Carga Viral
Palabras clave en ingles
HTLV-I InfectionsT-lymphotropic virus 1 Human
Gene Expression Regulation
Human
Interleukin-10
Proviruses
Sjogren's Syndrome
Tumor Necrosis
Viral Load
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