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2030-01-01
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ANAL HPV PREVALENCE AND ASSOCIATED FACTORS AMONG HIV-SEROPOSITIVE MEN UNDER ANTIRETROVIRAL TREATMENT IN BRAZIL
Author
Affilliation
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Social e Preventiva. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Médica em DST/IADS. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Obstetrícia e Ginecologia. Belo Horizonte, MG, Brasil.
Universidade Federal de São João Del Rey. São João Del Rey, MG, Brasil.
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil.
University of California San Francisco. San Francisco, CA, USa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Médica em DST/IADS. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Obstetrícia e Ginecologia. Belo Horizonte, MG, Brasil.
Universidade Federal de São João Del Rey. São João Del Rey, MG, Brasil.
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil.
University of California San Francisco. San Francisco, CA, USa.
Abstract
Background: The incidence of anal cancer has increased in
developed countries. There is evidence that high-grade anal intraepithelial
neoplasia and anal cancer are both linked to some human
papillomavirus (HPV) infections. There are scarce data on anal
cancer or male anal HPV infection in Brazil.
Objective: The purpose of this study was to assess the prevalence of
anal HPV infection and associated risk factors, stratified by oncogenic
and nononcogenic types, in a sample of HIV-seropositive men in Brazil.
Methods: Multicenter cross-sectional study of HIV-seropositive
male patients attending public AIDS clinics in urban Brazil.
Participants were interviewed for sociodemographic and behavioral
characteristics. Anal HPV specimens were collected with a moistened
Dacron swab inserted into the anal and stored in ThinPrep solution.
HPV DNA–positive samples were typed by dot-blot hybridization.
The prevalences of oncogenic and nononcogenic HPV types were
calculated and multinomial logistic regression was used to assess
independent predictors of HPV infection.
Results: Among 445 men, 65.6% were positive for HPV DNA in the
anal canal. Oncogenic types were detected in 40.7%. Logistic
regression indicated that lifetime history of sexual intercourse only
with men or with men and women; receptive anal intercourse in the
last 12 months; and CD4+ lymphocyte count below 200 cells per
cubic millimeter were independently associated with the detection of
anal HPV infection.
Conclusions: The high prevalence of anal HPV infection in this
cross-sectional study underscores the need for studying and
implementing screening programs of high-risk groups in Brazil.
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