Plasma biomarkers profile of female dogs with mammary carcinoma and its association with clinical and pathological features

Universidade Federal da Bahia. Escola de Medicina Veterinaria. Departamento de Patologia e Clínica. Salvador, BA, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Patologia Geral. Laboratorio de Patologia Comparada. Belo Horizonte, MG, Brasil
Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil
Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Escola de Veterinaria. Departamento de Clínica e Cirurgia Veterinarias. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Patologia Geral. Laboratorio de Patologia Comparada. Belo Horizonte, MG, Brasil
Universidade Federal da Bahia. Escola de Medicina Veterinaria. Departamento de Patologia e Clínica. Salvador, BA, Brasil
Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil
Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Patologia Geral. Laboratorio de Patologia Comparada. Belo Horizonte, MG, Brasil

Resumen en ingles

The immunological biomarkers profiles were evaluated using Luminex as putative measures to monitor canine mammary carcinomas (MCs). Forty female dogs were categorized into benign mixed tumour (MC-BMT = 28) and mammary carcinoma (MC=12). The ascendant biomarker signatures were used to compare the groups. For example, a higher frequency of MC-BMT animals producing IL-6, CXCL-8 and CXCL-10 was observed, whereas for the MC group IL-2 and CXCL-8 were detected. MC-BMT animals without metastasis had an increase in the levels of IL-2, CXCL-8, CXCL-10, IL-6, TNF-α, IL-15 and a decrease in IL-10 and CXCL-8. MC-BMT animals with metastasis showed only an increase in CXCL-10 and a decrease in IL-18. After comparing the ascendant signatures following the presence of metastasis in both groups, a higher frequency of dogs exhibiting IL-10 production was observed. Pearson correlation (P = 0.0273) and receiver operating characteristic (ROC) curve analysis revealed that this pattern was associated with worse outcome and lower survival rates in MC animals.

Palabras clave en portugues

patologia clinica
cancer/metastase

Palabras clave en ingles

clinical pathology
comparative oncology
immunology
metastasis
oncology
clinical pathology
comparative oncology
metastasis

Editor

John Wiley & Sons

Referencia

LIMA, Alessandra Estrela da Silva et al. Plasma biomarkers profile of female dogs with mammary carcinoma and its association with clinical and pathological features. Veterinary and Comparative Oncology, v. 14, n.1, p. 88–100, 2016

ISSN

1476-5829

Por favor, use este identificador para citar o enlazar este ítem: https://www.arca.fiocruz.br/handle/icict/16715

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2028-01-01

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