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DIFFERENTIAL GEL ELECTROPHORESIS (DIGE) EVALUATION OF NAPHTHOIMIDAZOLES MODE OF ACTION: A STUDY IN TRYPANOSOMA CRUZI BLOODSTREAM TRYPOMASTIGOTES
Doença de Chagas
América Latina
Tripomastigotas da corrente sanguínea
Eletroforese em Gel
Naphthoimidazoles
Trypanosoma cruzi
Bloodstream Trypomastigotes
Chagas disease
Latin America
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Resumen en ingles
The obligate intracellular protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a neglected illness affecting millions of people in Latin America that recently entered non-endemic countries through immigration, as a consequence of globalization. The chemotherapy for this disease is based mainly on benznidazole and nifurtimox, which are very efficient nitroderivatives against the acute stage but present limited efficacy during the chronic phase. Our group has been studying the trypanocidal effects of naturally occurring quinones and their derivatives, and naphthoimidazoles derived from β-lapachone N1, N2 and N3 were the most active. To assess the molecular mechanisms of action of these compounds, we applied proteomic techniques to analyze treated bloodstream trypomastigotes, which are the clinically relevant stage of the parasite.
Palabras clave en portugues
Trypanosoma cruziDoença de Chagas
América Latina
Tripomastigotas da corrente sanguínea
Eletroforese em Gel
Palabras clave en ingles
Gel Electrophoresis (DIGE)Naphthoimidazoles
Trypanosoma cruzi
Bloodstream Trypomastigotes
Chagas disease
Latin America
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