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IN SILICO PREDICTED EPITOPES FROM THE COOH-TERMINAL EXTENSION OF CYSTEINE PROTEINASE B INDUCING DISTINCT IMMUNE RESPONSES DURING LEISHMANIA (LEISHMANIA) AMAZONENSIS EXPERIMENTAL MURINE INFECTION
infecção murina
B proteinase cisteína
Respostas imunes
CPB COOH-terminal extension
murine infection
immune responses
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Affilliation
Abstract
Leishmania parasites have been reported to interfere and even subvert their host immune responses to enhance their chances of survival and proliferation. Experimental Leishmania infection in mice has been widely used in the identification of specific parasite virulence factors involved in the interaction with the host immune system. Cysteine-proteinase B (CPB) is an important virulence factor in parasites from the Leishmania (Leishmania) mexicana complex: it inhibits lymphocytes Th1 and/or promotes Th2 responses either through proteolytic activity or through epitopes derived from its COOH-terminal extension. In the present study we analyzed the effects of Leishmania (Leishmania) amazonensis CPB COOH-terminal extension-derived peptides on cell cultures from murine strains with distinct levels of susceptibility to infection: BALB/c, highly susceptible, and CBA, mildly resistant.
Keywords in Portuguese
Leishmania amazonensisinfecção murina
B proteinase cisteína
Respostas imunes
Keywords
Leishmania (Leishmania) amazonensisCPB COOH-terminal extension
murine infection
immune responses
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