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CHARACTERIZATION OF FULL-LENGTH HIV-1 CRF17_BF GENOMES AND COMPARISON TO THE PROTOTYPE CRF12_BF STRAINS
Aulicino, Paula C. et al. | Fecha del documento: 2012
Autor
Aulicino, Paula C.
Gómez-Carrillo, Manuel
Bello, Gonzalo
Rocco, Carlos
Mangano, Andrea
Carr, Jean
Sen, Luisa
Foley, Brian
Afiliación
Hospital de Pediatría J. P. Garrahan. Laboratorio de Biología Celular y Retrovirus-CONICET. Buenos Aires, Argentina.
Universidade de Buenos Aires. Escola de Medicina. Departamento de Microbiologia. Centro Nacional de Referência em AIDS. Buenos Aires, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Hospital de Pediatría J. P. Garrahan. Laboratorio de Biología Celular y Retrovirus-CONICET. Buenos Aires, Argentina.
Hospital de Pediatría J. P. Garrahan. Laboratorio de Biología Celular y Retrovirus-CONICET. Buenos Aires, Argentina.
University of Maryland. School of Medicine. Institute of Human Virology. Department of Epidemiology and Prevention. Baltimore, MD, USA.
Hospital de Pediatría J. P. Garrahan. Laboratorio de Biología Celular y Retrovirus-CONICET. Buenos Aires, Argentina.
Los Alamos National Laboratory. Theoretical Biology Group. Los Alamos, USA.
Resumen en ingles
The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.
Palabras clave en portugues
subtipos de HIV-1
Argentina
Epidemiologia molecular
 
Palabras clave en ingles
HIV-1 subtypes
Argentina
BF recombinants
HIV diversity
Molecular epidemiology
CRF17_BF
 
Editor
Elsevier
Referencia
AULICINO, Paula C. et al. Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains. Infect Genet Evol., v.12, n.2, p.443-447, Mar. 2012.
DOI
10.1016/j.meegid.2012.01.003
ISSN
1567-1348