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BCG (BACILLE OF CALMETTE–GUÉRIN) REVACCINATION LEADS TO IMPROVED IN VITRO IFN- RESPONSE TO MYCOBACTERIAL ANTIGEN INDEPENDENT OF TUBERCULIN SENSITIZATION IN BRAZILIAN SCHOOL-AGE CHILDREN
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Resumo em Inglês
Tuberculin skin test (TST) response and cytokine production in finger stab-derived whole blood cultures from 136 BCG scar-positive
school-age children were evaluated before and after BCG revaccination. Fifty-four percent of the children increased in vitro production
of IFN- after revaccination, and this increase was highly significant for previously unresponsive children (P < 0.0001). No correlation
was found between TST response and cytokine production. Our data suggest that the in vitro IFN- response to mycobacterial antigens
can be boosted by BCG revaccination and may contribute to the search of correlates of protection to be used for the evaluation of new
mycobacterial vaccines.
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