Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/14647
ENHANCEMENT OF CHRONIC TRYPANOSOMA CRUZI MYOCARDITIS IN DOGS TREATED WITH LOW DOSES OF CYCLOPHOSPHAMIDE
Miocarditis
Cyclophosphamide
Chagas disease
Myocytes, cardiac
Animals
Dogs
Affilliation
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
An enhancement of chronic myocarditis was obtained
in dogs chronically infected with Trypanosoma cruzi
protozoa soon after they were submitted to treatment
with low doses of cyclophosphamide (50 mg/sq m bs
three times a week for 3 weeks). Such treatment did not
cause immunodepression. Myocarditis varied in intensity,
but was quite severe and diffuse in some animals,
with focal fibrinoid, coagulative, and lytic necrosis and
invasion of disintegrating myocardial fibers by the mononuclear inflammatory cells. Untreated infected
controls exhibited mild focal myocarditis, usually represented
by accumulation oflymphocytes in the interstitial
connective tissue. It is suggested that the administration
of low doses of cyclophosphamide interfered
with the immunologic suppressor network that is
thought to maintain the chronic indeterminate (or latent)
phase of T cruzi infection.
Keywords
Trypanosoma cruziMiocarditis
Cyclophosphamide
Chagas disease
Myocytes, cardiac
Animals
Dogs
Share